Slay the Spire 2
Home All pages
All vikis
Aion 2AnantaArcheAge ChroniclesCall of Duty: Modern Warfare 4Chrono OdysseyCivilization 3Civilization 4Crimson DesertDeadlockDiablo 4Diablo 5EnshroudedFableFinal Fantasy ResonanceGrand Theft Auto 6Heroes of Might and Magic 3Heroes of Might and Magic: Olden EraKingdom Come: Deliverance 2Path of Exile 2Phantom Blade ZeroSlay the Spire 2SoulframeValheimWitcher 3: Wild Hunt – Remastered
Start your own viki
Slay the Spire 2 1.0 release: Sep 2027Not announced: our best guess from Mega Crit's 1 to 2 year Early Access plan.
Best guessMega Crit's Early Access FAQ on Steam says it will stay in Early Access "Until the game feels great! Last time we thought it would be about a year and it took about 1.5 years. So perhaps in the same 1 - 2 year range." We count 18 months from the Mar 5, 2026 Early Access launch, as the first game took, to the first Thursday of Sep 2027 (Mega Crit ships on Thursdays) at 10 AM Pacific, the hour of the Early Access launch. Steam

10Months6Days

Potions

Slay the Spire 2 has 64 potions in OP.GG's v0.111.0 beta data (20 Common, 20 Uncommon, 20 Rare and 4 event or token potions), and you start each run with 3 potion slots, one fewer from Ascension 4 (Tight Belt). Fifteen character potions and six shared ones are unlocked through Epochs.

Slay the Spire 2 has 64 potions in OP.GG's potion list, read from the game data of the v0.111.0 public beta (Aug 14, 2026): 20 Common, 20 Uncommon, 20 Rare, and 4 that come only from events or relics. One of those, Ambergris, exists only on the public beta, so the main branch (v0.107.1, Jun 19, 2026) has 63. A potion is a one-use effect, and you start each run with 3 potion slots, per Mobalytics' beginner guide (Mar 19, 2026); Ascension 4 takes one away. Potions drop after fights, are sold by the Merchant and come from events and relics. The game is in Early Access, so potion effects can still change.

Quick facts

Potions 64 in OP.GG's beta v0.111.0 data; 63 on the main branch
Rarities Common 20, Uncommon 20, Rare 20, Event and Token 4
Potion slots 3 at the start of a run
Ascension 4 Tight Belt: "Start each run with one less potion slot."
More slots Potion Belt (+2), Phial Holster (+1), Alchemical Coffer (+4, filled)
Character potions 15, three per character, unlocked by each character's Act 3 Epoch
Merchant Sells 3 potions per visit, per Game Rant
Co-op Potions can be used on allies

Sources: OP.GG: Complete Potion List (beta v0.111.0); Mobalytics: Ultimate Beginner Guide; PCGamesN: All Ascension levels; Spire Codex: Epochs (game data); Game Rant: Essential Tips.

Common potions

The effect text in each table is OP.GG's, from the v0.111.0 beta's game data, read Oct 26, 2026.

Potion Character Effect
Attack Potion Choose 1 of 3 random Attacks to add into your Hand; it's free to play this turn
Block Potion Gain 12 Block
Blood Potion Ironclad Heal for 20% of your Max HP
Colorless Potion Choose 1 of 3 random Colorless cards to add into your Hand; it's free to play this turn
Dexterity Potion Gain 2 Dexterity
Energy Potion Gain 2 Energy
Explosive Ampoule Deal 10 damage to ALL enemies
Fire Potion Deal 20 damage
Flex Potion Gain 5 Strength; lose it at the end of your turn
Focus Potion Defect Gain 2 Focus
Poison Potion Silent Apply 6 Poison
Potion of Doom Necrobinder Apply 33 Doom
Power Potion Choose 1 of 3 random Powers to add into your Hand; it's free to play this turn
Skill Potion Choose 1 of 3 random Skills to add into your Hand; it's free to play this turn
Speed Potion Gain 5 Dexterity; lose it at the end of your turn
Star Potion Regent Gain 3 Stars
Strength Potion Gain 2 Strength
Swift Potion Draw 3 cards
Vulnerable Potion Apply 3 Vulnerable
Weak Potion Apply 3 Weak

Source: OP.GG potion list (game data, beta v0.111.0), read Oct 26, 2026.

Uncommon potions

Potion Character Effect
Ashwater Ironclad Exhaust any number of cards in your Hand
Blessing of the Forge Upgrade all cards in your Hand for the rest of combat
Bone Brew Necrobinder Summon 15
Clarity Extract Draw 1 card; at the start of your next 3 turns, draw 1 additional card
Cunning Potion Silent Add 3 Upgraded Shivs into your Hand
Cure All Gain 1 Energy and draw 2 cards
Duplicator This turn, your next card is played an extra time
Fortifier Triple your Block
Fysh Oil Gain 1 Strength and 1 Dexterity
Gambler's Brew Discard any number of cards, then draw that many
Heart of Iron Gain 7 Plating
King's Courage Regent Forge 15
Liquid Bronze Gain 3 Thorns
Potion of Binding Apply 1 Weak and 1 Vulnerable to ALL enemies
Potion of Capacity Defect Gain 2 Orb Slots
Powdered Demise Enemy loses 9 HP at the end of each of its turns
Radiant Tincture Gain 1 Energy, and Energy at the start of your next 3 turns
Regen Potion Gain 5 Regen
Stable Serum Retain your Hand for 2 turns
Touch of Insanity A card in your Hand is free to play this combat

Source: OP.GG potion list (game data, beta v0.111.0), read Oct 26, 2026.

On the public beta since v0.108.0 (Jul 3, 2026), Regen Potion healing resolves before Doom, so it can save a Necrobinder from self-Doom; on the main branch Doom still checks first.

Rare potions

Potion Character Effect
Beetle Juice Enemy's attacks deal 30% less damage for the next 4 turns
Bottled Potential Shuffle ALL your cards into your Draw Pile, draw 5 cards
Cosmic Concoction Regent Add 3 Upgraded Colorless cards into your Hand
Distilled Chaos Play the top 3 cards of your Draw Pile
Droplet of Precognition Choose a card in your Draw Pile and add it into your Hand
Entropic Brew Fill all your empty potion slots with random potions
Essence of Darkness Defect Channel a Dark for each of your Orb Slots
Fairy in a Bottle When your HP would be reduced to 0, the potion is discarded and you heal to 30% of your Max HP
Fruit Juice Gain 5 Max HP
Ghost in a Jar Silent Gain 1 Intangible
Gigantification Potion The next Attack you play deals triple damage
Liquid Memories Put a card from your Discard Pile into your Hand; it's free to play this turn
Lucky Tonic Gain 1 Buffer
Mazaleth's Gift Gain 1 Ritual
Orobic Acid Add a random Attack, Skill, and Power into your Hand, free to play this turn
Pot of Ghouls Necrobinder Add 2 Souls into your Hand
Shackling Potion ALL enemies lose 7 Strength this turn
Ship in a Bottle Gain 10 Block, and 10 Block next turn
Snecko Oil Draw 7 cards and randomize the cost of cards in your Hand this turn
Soldier's Stew Ironclad All cards containing Strike gain 1 Replay this combat

Source: OP.GG potion list (game data, beta v0.111.0), read Oct 26, 2026.

Fairy in a Bottle has one known exception. Mega Crit explained in Major Update #1 (Apr 17, 2026) that it triggers only when your HP reaches 0, so it does not save you when the Act 2 boss The Insatiable eats you, which is death "by any other means".

Event and token potions

Four potions never drop from normal rewards: three come from events and one from a relic.

Potion Where it comes from Effect
Ambergris Neow's Sacrifice (Neow relic, public beta since v0.109.0) Heal for 50% of your Max HP; if used in combat, take an extra turn
Foul Potion Potion Courier event ("Grab Potions: Procure 3 Foul Potions") Deal 12 damage to ALL players and enemies; throw it at the Merchant for 100 Gold instead
Glowwater Potion Drowning Beacon event ("Bottle") Exhaust your Hand and draw 10 cards
Potion-Shaped Rock Petrified Toad relic, each combat (token) Deal 15 damage

Sources: OP.GG potion list and event pages for Potion Courier and Drowning Beacon (v0.111.0), read Oct 26, 2026; Mega Crit: Beta Patch Notes v0.109.0 (Jul 17, 2026).

The Foul Potion does not hit Osty, a wording Mega Crit fixed in v0.102.0 (Apr 3, 2026). Throwing one at the Merchant normally pays 100 Gold, but it can also start the secret fight with "The Merchant???", who has 165 HP and drops his relic stock, his rug and 300 Gold, per TheGamer (Mar 17, 2026). See Merchant and Rest Sites.

Potion slots and Tight Belt

Every run starts with 3 potion slots. Mobalytics advises using a potion when you are at the cap "in case you're offered another". Ascension 4, Tight Belt, reads "Start each run with one less potion slot", per PCGamesN (Mar 10, 2026), so from Ascension 4 up you start with 2.

Relics change the count. Per OP.GG's relic list and its Ancient pages (v0.111.0 data):

Relic Rarity or source Potion effect
Potion Belt Common Upon pickup, gain 2 potion slots
Phial Holster Neow Gain 1 potion slot and procure 2 random Potions
Alchemical Coffer Orobas (Act 2) Gain 4 potion slots filled with random Potions
Delicate Frond Nonupeipe (Act 3) At the start of each combat, fill all empty potion slots with random Potions
Lost Coffer Neow Gain 1 card reward and procure 1 random potion
Tiny Mailbox Uncommon Whenever you Rest, procure 2 random Potions
White Beast Statue Rare Potions always appear in combat rewards
Cauldron Shop Brews 5 random Potions
Petrified Toad Uncommon Procure a Potion-Shaped Rock at the start of each combat
Reptile Trinket Uncommon Whenever you use a potion, gain 3 Strength this turn
Belt Buckle Shop 2 Dexterity while you have no Potions
Sozu Darv (Ancient) Gain 1 Energy each turn; you can no longer obtain Potions

Potion Belt is in S tier on Mobalytics' relic tier list (Jul 27, 2026). Events also trade potions: Whispering Hollow sells 2 random Potions for 35 Gold, the Stone of All Time takes a random Potion for 10 Max HP, and The Future of Potions? turns a Potion into an Upgraded card of matching rarity and type (see Events).

Potions unlocked by Epochs

Not every potion is in the pool from the start: seven Epochs on the Timeline add three potions each, per the game data that Spire Codex reads. Each character's Act 3 Epoch, earned by beating Act 3 with that character, adds its three character potions (and unlocks Ascension for it). See Unlocks and the Timeline.

Epoch Unlocked by Potions
The Pact Beating Act 3 with the Ironclad Blood Potion, Soldier's Stew, Ashwater
Trophies Beating Act 3 with the Silent Poison Potion, Ghost in a Jar, Cunning Potion
Grand Strategy Beating Act 3 with the Regent Star Potion, Cosmic Concoction, King's Courage
Spireborn Beating Act 3 with the Necrobinder Potion of Doom, Pot of Ghouls, Bone Brew
Resolving Bugs Beating Act 3 with the Defect Focus Potion, Essence of Darkness, Potion of Capacity
Open Not stated by a source Beetle Juice, Mazaleth's Gift, Droplet of Precognition
The Calm Not stated by a source Powdered Demise, Ship in a Bottle, Touch of Insanity

Source: Spire Codex: Epochs (game data), read Oct 26, 2026; Epoch conditions from Destructoid's Epoch guide (Mar 7, 2026), which also lists the Open potions.

Potions in co-op

In Co-op Multiplayer you can give potions to allies. TheGamer (Mar 10, 2026) says potions can be used on allies, and Mobalytics' co-op guide (Jun 2, 2026) names Block Potion and Energy Potion as examples. On the public beta since v0.109.0 (Jul 17, 2026), "you can now play nearly any potion on another player". Potions are not shared: each player has their own, per PC Gamer (Mar 24, 2026).

Best potions

Guides rate potions by when they help, not on one scale. Mobalytics' potion tier list by JapaneseExport (updated Jul 27, 2026) sorts them into Good Always, Good Early, Good Late, Niche/Average and Mediocre, and includes event potions. Its Good Always group includes Ghost in a Jar, Orobic Acid, Focus Potion, Touch of Insanity, Beetle Juice, Potion of Doom, Cure All, Distilled Chaos, Duplicator, Snecko Oil, Heart of Iron, Liquid Memories, Weak Potion, Blood Potion, Regen Potion and Energy Potion. It rates Attack, Fire, Block, Strength, Poison and Vulnerable potions Good Early, Fairy in a Bottle, Gambler's Brew, Swift Potion and Potion of Capacity Good Late, and Speed Potion its only Mediocre pick.

Guides agree you should not hoard potions. TheGamer's Collin MacGregor (Mar 9, 2026) says you get a chance at a free potion after each fight, so use them when a fight goes badly rather than save them for the boss, and check the Merchant's potions. Mobalytics says potions "are not just for bosses".

Some potions suit particular fights. PC Gamer's Abigail Shannon (Mar 13, 2026) recommends an Attack Potion against the Act 1 boss Vantom, whose Slippery turns each hit into 1 damage, and says a Duplication potion usually is not a good fit there.

Potion art

Potions have their own sprites in the sequel. Mega Crit wrote in its August 2025 Neowsletter that each potion got a distinct look and "very rare potions can look quite exotic too".

Frequently asked questions

How many potions are in Slay the Spire 2? OP.GG counts 64 potions in Slay the Spire 2's v0.111.0 public-beta data: 20 Common, 20 Uncommon, 20 Rare and 4 event or token potions. Ambergris is beta-only, so the main branch has 63.

How many potion slots do you get in Slay the Spire 2? You start a Slay the Spire 2 run with 3 potion slots, per Mobalytics, and Ascension 4 (Tight Belt) removes one. Potion Belt adds 2, Phial Holster 1 and Orobas' Alchemical Coffer 4 filled slots.

What are the best potions in Slay the Spire 2? Mobalytics' Jul 27, 2026 potion tier list rates Ghost in a Jar, Orobic Acid, Duplicator, Distilled Chaos, Snecko Oil, Liquid Memories and Energy Potion among Slay the Spire 2's "Good Always" potions. Speed Potion is its only "Mediocre" pick.

How do you get a Foul Potion in Slay the Spire 2? Foul Potions come only from Slay the Spire 2's Potion Courier event, whose "Grab Potions" choice gives 3 of them, per OP.GG. Thrown at the Merchant, each pays 100 Gold or starts the Fake Merchant fight.

Does Fairy in a Bottle work against The Insatiable in Slay the Spire 2? No: Mega Crit said in Major Update #1 that Slay the Spire 2's Fairy in a Bottle triggers only when your HP reaches 0, and The Insatiable kills you another way.

How do you unlock character potions in Slay the Spire 2? In Slay the Spire 2 each character's three potions are unlocked by its Act 3 Epoch, earned by beating Act 3 with that character, per Spire Codex: for example The Pact adds the Ironclad's Blood Potion, Soldier's Stew and Ashwater.

Can you give potions to other players in Slay the Spire 2? Yes: in Slay the Spire 2 co-op you can use potions on allies, per TheGamer. On the public beta since v0.109.0, nearly any potion can target another player.

Sources

Moments

Slay the Spire 2 Beginner’s Guide | Important Tips You Need to Know

IGN

  1. Slay the Spire 2 has 64 potions in OP.GG's potion list, read from the game data of the v0.111.0 public beta (Aug 14…

Slay The Spire 2's Next-Level Co-Op Makes It An Early GOTY Contender

GameSpot

  1. In Co-op Multiplayer you can give potions to allies. TheGamer (Mar 10, 2026) says potions can be used on allies, and…

10 Things That Instantly Improved My Runs | Slay the Spire 2 Tips & Guide

Nerdy Hickey

  1. Guides agree you should not hoard potions. TheGamer's Collin MacGregor (Mar 9, 2026) says you get a chance at a free…

The Secret to Beating EVERY Boss on Ascension 10 | Slay the Spire 2 Guide

vmService

  1. Some potions suit particular fights. PC Gamer's Abigail Shannon (Mar 13, 2026) recommends an Attack Potion against the…

Slay the Spire 2 - 15 Biggest Changes From Slay the Spire 1

IGN

  1. Potions have their own sprites in the sequel. Mega Crit wrote in its August 2025 Neowsletter that each potion got a…

Every page

See also

Last updated Oct 26, 2026 by the Vi.ki team. Page text CC BY-SA 4.0.

Edit History

Hotkeys

/
Jump to the search box
? or Ctrl + /
Open this list
Esc
Close this list, the photo viewer, or the account menu

Video

Space or K
Play or pause
← →
Back or forward 5 seconds
J L
Back or forward 10 seconds
0 to 9
Go to 0% to 90% of the video
, .
Previous or next frame, while paused
M
Mute or unmute
C
Captions on or off
F
Full screen on or off
A D
Previous or next moment

Photo viewer

← → or A D
Previous or next photo
↑ ↓ or W S
Previous or next photo
Home End
First or last photo
I
Show or hide the photo's info
C
Clickless on or off: a pointer over a thumbnail shows it
N
Compare with the last photo: back to the one shown before this, and N again comes back
Q
Move the thumbnails to the next edge: top, bottom, left and round
Ctrl + ,
Open or close the viewer's settings
V
Clickless pan: a zoomed photo follows the pointer, rather than being dragged
B
Browse on or off
Z
Everything out of the way: full screen, no thumbnails, no button bar. Z again puts them back.